Miles Sanderson experienced a medical problem shortly after his arrest on Wednesday.
Sanderson is wanted on charges including first-degree murder after attacks that left 10 people dead and 18 injured on Sunday.
Most of the victims were from the James Smith Cree Nation, and the community was in uproar and grief after the fatal stabbings.
Chief Wally Burns is scheduled to speak with other First Nations leaders in the community this morning.
They will also be joined by the RCMP and Minister of Crown and Indigenous Relations Marc Miller, Indigenous Services Minister Patty Hajdu and Public Safety Minister Marco Mendicino.
The First Nation gathered for the first vigil since the attacks Wednesday night as community members braced for more in the coming days.
The large gathering came just hours after RCMP announced Sanderson had been taken into custody near Rosthern following a police pursuit of a stolen vehicle.
The vehicle ended up in the ditch, driven into nearby foliage on the side of the highway.
RCMP Assistant Commissioner Rhonda Blackmore said shortly after the arrest, Sanderson experienced a medical problem.
He said officers performed life-saving measures and he was taken by ambulance to a Saskatoon hospital, where he was pronounced dead.
Blackmore said it means there may never be an answer to what led to the killings.
The only other suspect, Sanderson’s brother Damien, was found dead near one of the crime scenes on Monday.
This report by The Canadian Press was first published on September 9, 2022.